Ozone (O3) pollution is becoming the primary air pollution issue with the large decrease in fine particulate concentrations in eastern China. The development of widely recognized policies for controlling O3 pollution episodes is urgent. This study aims to provide actionable and comprehensive suggestions for O3 control policy development, with an emphasis on the precursor emission reductions. Here, we compared the impacts of different spatial scale reductions on a widespread O3 pollution episode in eastern China by a state-of-the-art regional air quality model. We find that region-scale joint control (in >30 cities) is much more effective than city-scale sporadic reduction in reducing O3 concentration. Sporadic controls only reduce the maximum daily 8-h average (MDA8) O3 by ∼1 μg/m3 in the controlled city, whereas regional controls lead to a MDA8 O3 decrease of ∼8 μg/m3 in the controlled region. In addition, the emission reduction effectiveness increased by 2.6 times from <5 cities to >30 cities. Continuous reductions have a cumulative effect on the decrease of MDA8 O3, showing the strongest effects within 24 h and diminishing after 48 h, which underscores the importance of reducing emissions 24 h prior to an episode. Moreover, the effect of control measures on MDA8 O3 varies spatially depending on the ratio of volatile organic compounds (VOCs) to nitrogen oxides (NOx) (VOCs/NOx). Both the reductions of VOC and NOx emissions have a positive effect on the decrease of MDA8 O3 in summer, but the effects of VOC reductions are 1.2 to 1.7 times higher than those of NOx reductions. The residential sector, due to its high VOCs/NOx emission ratio, exhibits the highest efficiency in the reduction of O3 concentrations. Our results highlight the importance of regional joint control and synergistic reduction of VOCs and NOx in eastern China. Display omitted •The synergistic effect of regional joint control increases with the expansion of emission reduction areas.•The emission control 24 h in advance has a strong cumulative effect on the reduction of O3 concentrations.•The response of MDA8 O3 changes to the emission reduction depends on the ratios of VOCs/NOx.•Reduction in residential sector is effective for O3 mitigation, while the industrial sector makes the largest contribution.