Although epidemiological studies report a lower risk of venous thromboembolism (VTE) than in the Western world, VTE rates in Asia may be underestimated. Furthermore, it is uncertain whether VTE outcomes differ in Asia and the rest of the world (ROW). GARFIELD-VTE is a global, prospective, non-interventional study of real-world treatment practices. In this study, we compared baseline characteristics, treatment patterns, and 12-month outcomes in Asia and ROW. Of the 10,684 enrolled patients, 1822 (17.1%) were Asian (China n = 420, Hong Kong n = 98, Japan n = 148, Malaysia n = 244, South Korea n = 343, Taiwan n = 232, Thailand n = 337). Compared with ROW patients, those from Asia were more often female (57.4% vs. 48.0%), non-smokers (74.0% vs. 58.9%) and had a lower BMI (24.8 kg/m2 vs. 29.1 kg/m2). Asian patients were more likely to be managed in the hospital (86.9% vs. 70.4%) and to have active cancer (19.8% vs. 8.1%) or a history of cancer (19.1% vs. 12.0%). Asian patients received no anticoagulation more frequently than ROW patients (6.5% vs. 2.1%). Over 12-months follow-up, the rate of all-cause mortality (per 100 person-years 95% confidence interval) was higher in Asians (15.2 13.4–17.3 vs. 5.9 5.4–6.5). Adjusted hazard ratios indicated a higher risk of all-cause mortality in Asian patients than the ROW (1.32 1.08–1.62). The frequencies of major bleeding and recurrent VTE were similar. Asian patients have different risk profiles, treatment patterns and a higher risk of mortality compared with the ROW. •GARFIELD-VTE compared VTE practices among Asian and non-Asian patients•Asian patients with VTE were more likely to have active or history of cancer•Asian patients with VTE were less likely to receive anticoagulation therapy•After adjustment, the risk of mortality was higher in Asians than non-Asians