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Samsoen, Simon; Dudognon, Émeline; Le Fer, Gaëlle; Fournier, David; Woisel, Patrice; Affouard, Frédéric
International journal of pharmaceutics, 03/2024, Letnik: 653Journal Article
Display omitted •Sur-saturated Curcumin/PVP amorphous solid dispersions (ASD) obtained by milling.•PVP low dispersity drastically increases glass transition temperature of ASD with Curcumin.•Shortest PVP chains reduce the anti-plasticisation effect of Curcumin-PVP interactions.•Solubility of Curcumin is increased in ASD formulated with well-defined PVP. Amorphous solid dispersions (ASD) are known to enhance the absorption of poorly water-soluble drugs. In this work we synthesise well-defined Polyvinylpyrrolidone (PVP) to establish the impact of dispersity and chain-end functionality on the physical properties of Curcumin (CUR)/PVP ASD. Thermodynamic characterisation of synthesised PVP emphasises a strong effect of the dispersity on the glass transition temperature (Tg), 50 °C higher for synthesised PVP than for commercial PVP K12 of same molar mass. This increase of Tg affects the thermodynamic properties of CUR/PVP ASD successfully formulated up to 70 wt% of CUR by milling or solvent evaporation. The evolution of both the Tg and CUR solubility values versus CUR content points out the development of fairly strong CUR-PVP interactions that strengthen the antiplasticising effect of PVP on the Tg of ASD. However, for ASD formulated with commercial PVP this effect is counterbalanced at low CUR content by a plasticising effect due to the shortest PVP chains. Moreover, the overlay of the phase and state diagrams highlights the strong impact of the polymer dispersity on the stability of CUR/PVP ASD. ASD formulated with low dispersity PVP are stable on larger temperature and concentration ranges than those formulated with PVP K12.
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