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  • Memory function in early he...
    Weissenborn, Karin; Heidenreich, Susanne; Giewekemeyer, Kathrin; Rückert, Norbert; Hecker, Hartmut

    Journal of hepatology, 09/2003, Letnik: 39, Številka: 3
    Journal Article

    Background: Early hepatic encephalopathy (HE) is characterized by deficits in motor performance, visual perception, visuo-constructive abilities and attention. Whether defective memory is a feature of early HE is controversial. Aims: To analyze memory function in patients with early HE. Methods: Memory tests were applied to cirrhotic patients with grade 0 HE, minimal HE and grade I HE ( n=45) and controls ( n=52). The battery included short and long term memory tests requiring free recall or recognition. Minimal HE was diagnosed by assessing the psychometric hepatic encephalopathy score using the PSE-Syndrom-Test and by carrying out a neurological examination. Group differences of the test results were analyzed using analysis of covariance. Results: HE 0 patients achieved test results similar to the controls in all but two tests. Patients with early HE (minimal and grade I HE) scored lower than the controls in all tests applied. A detailed analysis of test performance showed that the patients’ deficits were in attention and visual perception, rather than memory. Conclusions: Patients with early HE score lower than controls in memory tasks predominantly because of deficits in attention and visual perception.