Objective In Sweden, Consultation Liaison-psychiatry (CLP) has hitherto largely been practiced by enthusiasts with a lack of exchange and consensus on clinical practice. Hence, an important impetus for development has been lacking. In 2014, the Swedish Psychiatric Society initiated a work on clinical guidelines in CLP. Since 2019, a working group within the national CL Association has been responsible for this work. Methods To start with, clinical guidelines from other countries/languages were identified, and central issues and themes for practicing CL-psychiatrists were collected. After the formulation of a preliminary list of content, 21 authors for 25 chapters were identified. In the following process, a smaller editorial committee stayed in close touch with authors and presented drafts for external reviewers and for selected chapters. A Delphy-like process was initiated with participation from active CL-psychiatrists in Sweden (and partially Norway). Final drafts were then presented to the board of the Swedish Psychiatric Society and after minor modifications as result of their reviews a final version was agreed upon. Results The Swedish clinical guidelines on consultation-liaison psychiatry will encompass ca 280 pages in print, and will also be published online, in March 2022. Conclusions The development of clinical guidelines is feasible as a process within professional bodies outside of the official governmental institutions. It is anticipated that the guidelines will promote and accelerate the development of CL-psychiatry in countries were Swedish is understood, such as the Nordic countries.