Enhanced Chemotherapy Efficacy by Sequential Delivery of siRNA and Anticancer Drugs Using PEI-Grafted Graphene Oxide

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Enhanced Chemotherapy Efficacy by Sequential Delivery of siRNA and Anticancer Drugs Using PEI-Grafted Graphene Oxide

Zhang, Liming; Lu, Zhuoxuan; Zhao, Qinghuan; Huang, Jie; Shen, He; Zhang, Zhijun

Small (Weinheim an der Bergstrasse, Germany), February 18, 2011, Letnik: 7, Številka: 4

Journal Article

Loading and delivery of Bcl‐2‐targeted short interfering RNA (siRNA) and anticancer drug doxorubicin (DOX) by polyethylenimine (PEI)‐conjugated graphene oxide (PEI‐GO) is studied. A higher knockdown efficiency of siRNA delivered by PEI‐GO than by PEI is achieved. Sequential delivery of siRNA and DOX by the PEI‐GO nanocarrier shows a synergistic effect, which leads to significantly improved chemotherapy efficacy.

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Leto	Faktor vpliva		Izdaja		Kategorija		Razvrstitev
Leto	JCR	SNIP	JCR	SNIP	JCR	SNIP	JCR	SNIP

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