Abstract At present, laser deposition forming technology of titanium alloy is widely used based on the flexibility of laser additive manufacturing technology. However, the mechanism and law of influence on the forming accuracy and efficiency need further study. Based on the orthogonal experiment, the analysis of the results shows that with the increase of energy density, the forming accuracy and efficiency are improved. There is a negative correlation between precision and efficiency. The experimental data are fitted and analyzed by establishing a statistical regression analysis model, a regression prediction model is established, and the regression prediction model is comprehensively calculated and analyzed, so as to optimize the appropriate parameter interval. During the forming process, the energy density is maintained in the range of 300 J/mm2–400 J/mm2, the forming accuracy is at a high level of 80%, the forming efficiency can be maintained in a high range of 0.35 g/s-0.40 g/s, and the whole forming process is in a state of high precision and high efficiency, so that the matching strategy of precision and efficiency in the forming process is the best. In order to improve the laser deposition forming titanium alloy.