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Schütz, Rolf; Cantin, Michel; Roberts, Christopher; Greiner, Beate; Uhlmann, Eugen; Leumann, Christian
Angewandte Chemie (International ed.), April 3, 2000, Letnik: 39, Številka: 7Journal Article
Vive la différence! Replacement of the base‐linker amide functionality in peptide nucleic acids (PNAs) by an isostructural C−C double bond (shown schematically) leads to a dramatic change in DNA affinity, preferred strand orientation, and triplex‐forming properties, and thus highlights the importance of electrostatic properties over geometric properties of the amide functionality in PNA/DNA recognition.
