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Yaya, Amadou R.; Touaibia, Mohamed; Massarweh, Gassan; Rochon, Fernande D.; Breau, Livain
Steroids, 07/2010, Letnik: 75, Številka: 7Journal Article
17α-substituted ethynylestradiols, derived from estrone, were converted to their corresponding 17α-(bromo- or iodo-propargyl)estrone intermediates. Nucleophilic substitution onto these moieties with malonate diester followed by hydrolysis and complexation with cis-Pt(Me 2en)I 2 (Me 2en = N, N-dimethylethylenediamine) gave cis-Pt(Me 2en)(2-(3-(17β-estradiol-17α-yl)-prop-2-ynyl)malonato) 7, thus demonstrating that these estrogen-derived compounds can be used to synthesize stable Pt(II) complexes. The 3-(17β-estradiol-17α -yl)-prop-2-ynyl-1-sulfanylethylthiol 23 was also prepared.
