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Jiang, Shuxin; Yin, Huanan; Qi, Xiaohui; Song, Weiguo; Shi, Weiwei; Mou, Jiaojiao; Yang, Jie
Carbohydrate polymers, 01/2021, Letnik: 251Journal Article
•In this study, fCS-Sc was investigated for its macrophage activation effects.•fCS-Sc significantly promote the NO, TNF-α, IL-1β, and IL-6 production.•fCS-Sc activated macrophage through TLR4-NF-κB pathways. Sea cucumbers were nutritional food and traditional Chinese medicine. In this study, fucosylated chondroitin sulfate from sea cucumber Stichopus chloronotus (fCS-Sc), a potential anticoagulant agent and immunological adjuvant, was investigated for its immune activation effects on RAW 264.7 macrophage for the first time. The results indicated that fCS-Sc could significantly promote the proliferation, the pinocytic activity of RAW 264.7 cells, and the production of NO, TNF-α, IL-1β, and IL-6. The fluorescence labeling assay indicated that fCS-Sc could bind to the macrophage. Moreover, the specific pattern recognition receptor inhibition assays showed that toll-like receptor 4 (TLR4) and TLR2 were involved in the recognition of fCS-Sc. Western blot assays indicated that fCS-Sc could induce degradation of cytoplasm IκB-α, and promotion of NF-κB p65 subunit translocation to nucleus, leading to a functional improvement of macrophage through NF-κB pathway. The results suggested that fCS-Sc might served as a promising candidate of immunomodulator.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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