An African pygmy hedgehog ( Atalerix albiventris ) (APH) was admitted to the clinic with a history of vaginal bleeding. Examination showed poor clinical status of the patient based on haemogram values. The ultrasound showed an enlarged uterus filled with an anechoic content without the presence of free abdominal fluid. Ovariohysterectomy was performed under general inhalation anaesthesia. Histopathology examination was performed on tissue samples of the uterus with the final diagnosis of an endometrial polyp with endometrial cystic hyperplasia and chronic endometritis. In regard to the diagnostic findings, therapeutic option and postoperative care performed in this case, it is important to emphasize the fact that an early diagnosis of a reproductive disease contributes to proper treatment and a positive outcome. The endometrial polyp with cystic endometrial hyperplasia and chronic endometritis should be added to the list of differential diagnoses in cases where neoplasia of the reproductive system is suspected in an APH.