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Goti, Giulio; Colombo, Cinzia; Achilli, Silvia; Vivès, Corinne; Thépaut, Michel; Luczkowiak, Joanna; Labiod, Nuria; Delgado, Rafael; Fieschi, Franck; Bernardi, Anna
European journal of organic chemistry, August 5, 2022, 2022-08-05, Letnik: 2022, Številka: 29Journal Article
The Front Cover shows a blueprint for the design of a multivalent ligand of the C‐type lectin receptor DC‐SIGN. The compound features a tetravalent rigid scaffold that enables for the multivalent presentation of glycomimetics in a spatially defined fashion. This molecular architecture achieves strong binding avidity towards DC‐SIGN and increased selectivity over the C‐type lectin langerin, which is characterized by a distinct spatial arrangement of the carbohydrate recognition domains. Cover design by Mr. Francesco Frullini. More information can be found in the Research Article by F. Fieschi, A. Bernardi et al.
