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Li, Gang; Dilger, Andrew K.; Cheng, Peter T.; Ewing, William R.; Groves, John T.
Angewandte Chemie International Edition, January 26, 2018, Letnik: 57, Številka: 5Journal Article
The selective C−H functionalization of aliphatic molecules remains a challenge in organic synthesis. While radical chain halogenation reactions provide efficient access to many halogenated molecules, the use of typical protocols for the selective halogenation of electron‐deficient and strained aliphatic molecules is rare. Herein, we report selective C−H chlorination and fluorination reactions promoted by an electron‐deficient manganese pentafluorophenyl porphyrin catalyst, Mn(TPFPP)Cl. This catalyst displays superior properties for the aliphatic halogenation of recalcitrant, electron‐deficient, and strained substrates with unique regio‐ and stereoselectivity. UV/Vis analysis during the course of the reaction indicated that an oxo‐MnV species is responsible for hydrogen‐atom ion. The observed stereoselectivity results from steric interactions between the bulky porphyrin ligand and the intermediate substrate radical in the halogen rebound step. A deficiency that's a bonus: A highly electron‐deficient manganese porphyrin was found to effectively catalyze the radical halogenation of strained, electron‐deficient aliphatic substrates under mild conditions (see scheme). The bulkiness of the catalyst resulted in unique stereo‐ and regioselectivity.
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