The weldability is one of the key factors governing applications of TWinning-Induced Plasticity (TWIP) steels to automotive industries demanding high economy, environmental friendliness, and high performance. During spot welding of Zn-coated Al-containing TWIP steel sheets, liquid metal embrittlement (LME) frequently occurs by Zn infiltration into grain boundaries to form cracks, but the direct observation and detailed analysis of LME cracking are quite difficult because it occurs instantaneously within a second. Here in the present study, the LME was investigated by detailed microstructural evolutions of small Zn infiltrations or cracks as well as formation behavior of various intermetallic phases. In the heat-affected zone, the applied tensile stress and spot-welding heat tore down a diffusion-inhibiting Fe2Al5 layer formed between the Zn-coated layer and the TWIP steel substrate, and formed Zn-containing ferrite (α-Fe(Zn)) particles on the steel surface which provided paths for liquid Zn infiltration. α-Fe(Zn) particles played critical roles in accelerating the LME by reducing the ductility because they were brittle due to high contents of Zn and Al. In the present Al-containing TWIP steels, the increase in welding current generally aggravates the LME.