Sulfur(VI)‐fluoride exchange linkage as a next generation of click chemistry was introduced by Sharpless and coworkers in 2014. Distinguished from CuAAC, the SuFEx reaction proceeds under metal‐free conditions, and the reactive linkers are variable, enabling access to a diverse class of linkage compounds. Therein, a series of SuFEx linkers emerged has been widely prevalent in diverse fields. The SVI−F bond in comparison to SVI−Cl bond features excellent stability and chemoselectivity. The linkage chemistry primarily involves the formation of S−O and S−N bonds via commercially available phenols and amines, yet less study on C‐SuFEx linkage. This review will focus on three types of linkage for SuFEx linkers comprising S−O, S−N, and S−C bonds, and we hope to provide a practical guidance for SuFEx linkage chemistry. Sulfur(VI)‐fluoride exchange: This review summarizes recent advances in the linkage chemistry of S(VI) fluorides since 2014, emphasizing the formation of S−O, S−N, and S−C bonds. The divergent SuFEx linkage is deployed in the assembly of S(VI)‐containing compounds library.