The MErcury, Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) mission will send the first spacecraft to orbit the planet Mercury. A miniaturized set of seven instruments, along with the spacecraft telecommunications system, provide the means of achieving the scientific objectives that motivate the mission. The payload includes a combined wide- and narrow-angle imaging system; γ-ray, neutron, and X-ray spectrometers for remote geochemical sensing; a vector magnetometer; a laser altimeter; a combined ultraviolet-visible and visible-infrared spectrometer to detect atmospheric species and map mineralogical absorption features; and an energetic particle and plasma spectrometer to characterize ionized species in the magnetosphere.