Objectives. The aim of this study was to determine the most common disease symptoms in the Slovenian adult population, to determine their prevalence and to identify the demographic and other factors associated with higher prevalence of the symptoms. Methods. A cross-sectional observational study was conducted using computer assisted telephone interviewing - CATI thatcovered questions about the prevalence of 23 disease symptoms in the past month, their duration and general demographic information. The sample included 1,002 interviewees (age 15 - 90). Results. The results showed that the most common symptoms among Slovenian people are back pain (409 interviewees - 40.8%), joint pain (334 interviewees - 33.4%), excessive fatigue (308 interviewees - 30.7%), nervousness (285 interviewees - 28.4%), headache (280 interviewees - 27.9%), irritability (261 interviewees - 26.1%) and insomnia (259 interviewees - 25.8%). Disease symptoms occurred more often in women, the elderly, people with lower education and lower income, theunemployed, retired people and people with a chronic disease. The independent predictive factors for the presence of any symptoms were female gender and chronic disease. Conclusions. The prevalence of disease symptoms troubling the adult Slovenian population is high, as 77.3% of people suffer from at least one symptom. The study showed the population groups thatare most heavily burdened (females, the elderly, chronic patients, people with lower socio-economic status) and to which more attention should be paid in primary health care and prevention. Namen. Namen raziskave je bil ugotoviti, kateri bolezenski simptomi se najpogosteje pojavljajo pri odraslem prebivalstvu Slovenije in določiti njihovo prevalenco in dejavnike, ki nanjo vplivajo. Metode. Raziskava je bila presečna opazovalna in je potekala s pomočjo računalniško podprtega telefonskega anketiranja - CATI. Vključena sta bila 1002 prebivalca, stara med 15 in 90 let. Telefonski intervju je zajemal vprašanja o pojavnosti 23 bolezenskih simptomov, njihovem trajanju in o demografskih podatkih. Izsledki. Slovensko prebivalstvo ima najpogosteje težave z bolečinami v hrbtenici (409 oseb - 40,8 %), bolečinami v sklepih (334 oseb - 33,4 %), s prekomerno utrujenostjo (308 oseb - 30,7 %), z živčnostjo (285 oseb - 28,4 %), glavobolom (280 oseb - 27,9 %), razdražljivostjo (261 oseb - 26,1 %) in z nespečnostjo (259 oseb - 25,8 %). Statistično pogosteje so se bolezenski simptomi pojavljali pri ženskah, starejših, nižje izobraženih, ljudeh z nižjim osebnim dohodkom, nezaposlenih, upokojenih in tistih z znano kronično boleznijo. Neodvisna napovedna dejavnika za prisotnost vsaj enega bolezenskega simptoma sta ženski spol in prisotnost kronične bolezni. Sklepi. Slovensko prebivalstvo je znatno obremenjeno z bolezenskimi simptomi, saj 77,3 % vprašanih bremeni vsaj en bolezenski simptom. Raziskava je odkrila skupine prebivalstva, ki so bolezenskim simptomom še posebej podvržene (ženske, starejši, kronični bolniki, ljudje z nižjim socioekonomskim statusom) in katerim bi morala biti namenjena še posebna pozornost na ravni primarnega zdravstvenega varstva in preventivne dejavnosti