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Ishmail, Fatima-Zahra; Melis, Diana R.; Mbaba, Mziyanda; Smith, Gregory S.
Journal of inorganic biochemistry, February 2021, 2021-Feb, 2021-02-00, Letnik: 215Journal Article
A discrete series of tricarbonyl manganese and rhenium complexes conjugated to a quinoline-triazole hybrid scaffold were synthesised and their inhibitory activities evaluated against Plasmodium falciparum. In general, the complexes show moderate activity with improved inhibitory activities for the photoactivatable manganese(I) tricarbonyl complexes in the malaria parasite. All complexes are active in the dark against the NF54 CQS (chloroquine-sensitive) and K1 MDR (multidrug-resistant) strains of Plasmodium falciparum, with IC50 values in the low micromolar range. Of significance, the complexes retain their activity in the MDR strain with resistance indices ranging between 1.1 and 2.1. The Mn(I) analogues display photodissociation of all three CO ligands upon irradiation at 365 nm. More importantly, the complexes show increased antimalarial activity in vitro upon photoactivation, something not observed by the clinically used reference drug, chloroquine. As a purported mechanism of action, the compounds were evaluated as β-haematin inhibitors. To further understand the interactions of the complexes, in silico hemozoin docking simulations were performed, attesting to the fact that CO-release could be vital for blocking the hemozoin formation pathway. These results show that this strategy may be a valuable, novel route to design antimalarial agents with higher efficacy. Display omitted •Quinoline-triazole manganese and rhenium complexes were synthesised.•The complexes show good in vitro activity against Plasmodium falciparum in the dark.•The manganese complex shows enhanced antimalarial activity upon photoactivation.•The compounds show inhibition of β-haematin formation in a cell-free NP-40 assay.•In silico molecular docking simulations attest to the CO-release.
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