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Carlson, Bradley A.; Kwon, So Yeon; Chamorro, Mario; Oroszlan, Stephen; Hatfield, Dolph L.; Lee, Byeong Jae
Virology (New York, N.Y.), 03/1999, Letnik: 255, Številka: 1Journal Article
The possibility of whether tRNAs with and without a highly modified base in their anticodon loop may influence the level of retroviral ribosomal frameshifting was examined. Rabbit reticulocyte lysates were programmed with mRNA encoding UUU or AAC at the frameshift site and the corresponding Phe tRNA with or without the highly modified wyebutoxine (Y) base on the 3′ side of its anticodon or Asn tRNA with or without the highly modified queuine (Q) base in the wobble position of its anticodon added. Phe and Asn tRNAs without the Y or Q base, respectively, stimulated the level of frameshifting, suggesting that the frameshift event is influenced by tRNA modification status. In addition, when AAU occurred immediately upstream of UUU as the penultimate frameshift site codon, addition of tRNAAsnwithout the Q base reduced the stimulatory effect of tRNAPhewithout the Y base, whereas addition of tRNAAsnwith the Q base did not alter the stimulatory effect. The addition of tRNAAsnwithout the Q base and tRNAPhewith the Y base inhibited frameshifting. The latter studies suggest an interplay between the tRNAs decoded at the penulimate frameshift and frameshift site codons that is also influenced by tRNA modification status. These data may be intrepreted as indicating that a hypomodified isoacceptor modulates frameshifting in an upward manner when utilized at the frameshift site codon, but modulates frameshifting in a downward manner when utilized at the penultimate frameshift site codon.
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