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Thorpe, Thomas W; France, Scott P; Hussain, Shahed; Marshall, James R; Zawodny, Wojciech; Mangas-Sanchez, Juan; Montgomery, Sarah L; Howard, Roger M; Daniels, David S. B; Kumar, Rajesh; Parmeggiani, Fabio; Turner, Nicholas J
Journal of the American Chemical Society, 12/2019, Letnik: 141, Številka: 49Journal Article
Ene-reductases (EREDs) catalyze the reduction of electron-deficient CC bonds. Herein, we report the first example of ERED-catalyzed net reduction of CC bonds of enimines (α,β-unsaturated imines). Preliminary studies suggest their hydrolyzed ring-open ω-amino enones are the likely substrates for this step. When combined with imine reductase (IRED)-mediated CN reduction, the result is an efficient telescoped sequence for the preparation of diastereomerically enriched 2-substituted saturated amine heterocycles.
