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Webb, Lauren M; Oyesola, Oyebola O; Früh, Simon P; Kamynina, Elena; Still, Katherine M; Patel, Ravi K; Peng, Seth A; Cubitt, Rebecca L; Grimson, Andrew; Grenier, Jennifer K; Harris, Tajie H; Danko, Charles G; Tait Wojno, Elia D
The Journal of experimental medicine, 06/2019, Letnik: 216, Številka: 6Journal Article
Type 2 inflammation drives the clearance of gastrointestinal helminth parasites, which infect over two billion people worldwide. Basophils are innate immune cells that support host-protective type 2 inflammation during murine infection with the helminth However, the mechanisms required for basophil function and gene expression regulation in this context remain unclear. We show that during infection, basophils localized to the intestine and up-regulated Notch receptor expression, rendering them sensitive to Notch signals that rapidly regulate gene expression programs. In vitro, Notch inhibition limited basophil cytokine production in response to cytokine stimulation. Basophil-intrinsic Notch signaling was required for -elicited changes in genome-wide basophil transcriptional programs. Mice lacking basophil-intrinsic functional Notch signaling had impaired worm clearance, decreased intestinal type 2 inflammation, altered basophil localization in the intestine, and decreased CD4 T helper 2 cell responses following infection. These findings demonstrate that Notch is required for basophil gene expression and effector function associated with helminth expulsion during type 2 inflammation.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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