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Magnin, David R.; Taunk, Prakash C.; Robertson, James G.; Wang, Aiying; Marcinkeviciene, Jovita; Kirby, Mark S.; Hamann, Lawrence G.
Bioorganic & medicinal chemistry letters, 03/2006, Letnik: 16, Številka: 6Journal Article
The synthesis and dipeptidyl peptidase IV inhibitory activity of glycine- and alaninenitrile dipeptides are reported. A series of seco-prolinenitrile-containing dipeptides were synthesized and assayed as inhibitors of the N-terminal sequence-specific serine protease dipeptidyl peptidase IV, a promising new target for treatment of type 2 diabetes. The inhibitors described herein assess the minimum structural requirements at P1 for this enzyme, resulting in the identification of inhibitors with low nM potency.
