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Vincent‐Schneider, Hélène; Stumptner‐Cuvelette, Pamela; Lankar, Danielle; Pain, Sabine; Raposo, Graça; Benaroch, Philippe; Bonnerot, Christian
International immunology, 07/2002, Letnik: 14, Številka: 7Journal Article
Exosomes are small vesicles (60–100 nm) secreted by various cell types upon the fusion of endosomal compartments with the plasma membrane. Exosomes from antigen‐presenting cells (APC), such as B lymphocytes and dendritic cells (DC), bear MHC class II molecules. In addition, the injection of DC‐derived exosomes was reported to elicit potent T cell responses in vivo. Here, we analyzed the activation of specific T cells by MHC class II‐bearing exosomes in vitro. The rat mast cell line, RBL‐2H3, was engineered to express human class II molecules uniformly loaded with an antigenic peptide HLA‐DR1–hemagglutinin (HA). These cells secreted exosomes bearing DR1 class II molecules upon stimulation by a calcium ionophore or IgE receptor cross‐linking. Exosomes bearing DR1–HA(306–318) complexes activated HA/DR1‐specific T cells only weakly, whereas the cross‐linking of such exosomes to latex beads increased stimulation of specific T cells. By contrast, the incubation of free exosomes with DC resulted in the highly efficient stimulation of specific T cells. Thus, exosomes bearing MHC class II complexes must be taken up by professional APC for efficient T cell activation.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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