Purpose: Lung cancer (LC) and its treatment impose a significant burden on patients' life. However, patient-centered outcomes are rarely collected during patient follow-up. Filling this gap, the International Consortium for Health Outcomes Measurement (ICHOM) developed a standard set of variables for newly diagnosed LC patients. In order to facilitate the use of this standard set, the project aims to adapt it to the Spanish setting. Methods: The variables (instrument and periodicity) to be included in Spanish standard set were selected through consensus during 4 nominal groups (13 oncologists, 14 hospital pharmacists, 4 hospital managers and 3 LC patients), under the supervision of a Scientific Committee (1 oncologist, 3 hospital pharmacists, 2 LC patients advocates). Results: The variables agreed upon included: (1) case-mix: demographic age, sex, education and social-family support, clinical weight loss, smoking status, comorbidities (Charlson index), pulmonary function (FEV-1), tumor histology, clinical, and pathological stage (TNM), EGFR, ALK, ROS-1, PD-L1 and treatment factors intent and completion and (2) outcomes: degree of health performance status (ECOG) and quality-of-life (EQ-5D, LCSS), survival overall survival and cause of death, quality of death place of death, end-of-life care and palliative care, death aligned with living will, treatment complications, and others date of diagnosis and treatment initiation, productivity loss (sick leave). Conclusion: The adaptation of ICHOM standard set to the Spanish setting pave the way to standardize the collection of variables in LC.