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Rong, Jian; Deng, Ling; Tan, Ping; Ni, Chuanfa; Gu, Yucheng; Hu, Jinbo
Angewandte Chemie, February 18, 2016, Letnik: 55, Številka: 8Journal Article
The radical fluoroalkylation of isocyanides with fluorinated sulfones is enabled by visible‐light photoredox catalysis. A wide range of readily available mono‐, di‐, and trifluoromethyl heteroaryl sulfones can thus be used as efficient radical fluoroalkylation reagents under mild conditions. This method not only describes a new synthetic application of fluorinated sulfones, but also provides a new route to fluoroalkyl radicals. Sulfones in the spotlight: The radical fluoroalkylation of isocyanides with a wide range of readily available mono‐, di‐, and trifluoromethyl heteroaryl sulfones is enabled by visible‐light photoredox catalysis. Fluorinated sulfones can thus be used as precursors of fluoroalkyl radicals.
