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Burney, Sarah; Wenzel, Ringo; Kottke, Tilman; Roussel, Thomas; Hoang, Nathalie; Bouly, Jean-Pierre; Bittl, Robert; Heberle, Joachim; Ahmad, Margaret
Angewandte Chemie (International ed.), September 10, 2012, Letnik: 51, Številka: 37Journal Article
A quick switch: A single amino acid substitution at a conserved residue (D396N) of Arabidopsis cryptochrome‐1 (Atcry1) confers single‐stranded DNA repair activity in vitro, conferring photolyase activity onto the cryptochrome (see graph). The mutant protein undergoes photoreduction of flavin to the fully reduced anionic form, similar to photolyases and unlike wild‐type cryptochromes.
