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Tansey, Katherine E; Guipponi, Michel; Hu, Xiaolan; Domenici, Enrico; Lewis, Glyn; Malafosse, Alain; Wendland, Jens R; Lewis, Cathryn M; McGuffin, Peter; Uher, Rudolf
Biological psychiatry (1969), 04/2013, Letnik: 73, Številka: 7Journal Article
Background Pharmacogenetic studies aiming to personalize the treatment of depression are based on the assumption that response to antidepressants is a heritable trait, but there is no compelling evidence to support this. Methods We estimate the contribution of common genetic variation to antidepressant response with Genome-Wide Complex Trait Analysis in a combined sample of 2799 antidepressant-treated subjects with major depressive disorder and genome-wide genotype data. Results We find that common genetic variants explain 42% (SE = .180, p = .009) of individual differences in antidepressant response. Conclusions These results suggest that response to antidepressants is a complex trait with substantial contribution from a large number of common genetic variants of small effect.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Vir: Osebne bibliografije
in: SICRIS
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