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  • Development of the summary ...
    Yepes-Nuñez, Juan José; Li, Shelly-Anne; Guyatt, Gordon; Jack, Susan M; Brozek, Jan L; Beyene, Joseph; Murad, M. Hassan; Rochwerg, Bram; Mbuagbaw, Lawrence; Zhang, Yuan; Flórez, Ivan D; Siemieniuk, Reed A; Sadeghirad, Behnam; Mustafa, Reem; Santesso, Nancy; Schünemann, Holger J

    Journal of clinical epidemiology, 11/2019, Letnik: 115
    Journal Article

    AbstractObjectivesThe aim of the study was to develop a Grading of Recommendations, Assessment, Development and Evaluation (GRADE) summary of findings (SoF) table format that displays the critical information from a network meta-analysis (NMA). Study Design and SettingWe applied a user experience model for data analysis based on four rounds of semistructured interviews. ResultsWe interviewed 32 stakeholders who conduct or use MA. Four rounds of interviews produced six candidate NMA-SoF tables. Users found a final NMA-SoF table that included the following components highly acceptable: (1) details of the clinical question (PICO), (2) a plot depicting network geometry, (3) relative and absolute effect estimates, (4) certainty of evidence, (5) ranking of treatments, and (6) interpretation of findings. ConclusionUsing stakeholder feedback, we developed a new GRADE NMA-SoF table that includes the relevant components that facilitate understanding NMA findings and health decision-making.