Sensitivity analysis of the knee joint response to variations in gait kinematics-kinetics as reported in the literature is crucial for improved understanding and more effective prevention-treatment strategies. Using our validated finite element-musculoskeletal (FE-MS) model of lower extremity, we investigate the sensitivity of knee anterior cruciate ligament (ACL), muscle, and contact forces plus stability to the reported scatter in asymptomatic gait data. Three highly loaded stance instants (25, 50 and 75%) with five levels (mean, ±0.5SD and ±SD) for each of six knee joint angles-moments are used employing Taguchi approach (25 experiments) and regression equations. ACL force drops significantly at larger flexion angles (all periods) and smaller internal moment (at 75% only) but increases with the flexion moment. Tibiofemoral (TF) medial-lateral contact force partitioning is found, contrary to the common claim, most sensitive to changes in the adduction angle and not in the adduction moment. Total TF contact force increases significantly at greater moments (but not angles), especially in the sagittal plane. Forces in lateral hamstrings are significantly influenced by changes in adduction angles-moments. Larger flexion moments (at 25 and 50%) significantly increase forces in quadriceps and on patellofemoral (PF) contact. Sagittal moment, adduction moment (at 75%) and flexion angle (at 25%) contribute most to the joint stability. A strong inverse correlation exists between the joint stability and the total TF compression force. These findings can be exploited to adapt and modify intact, injured and reconstructed knee joint responses during gait.