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Li, Jingchao; Yu, Xiangrong; Jiang, Yuyan; He, Shasha; Zhang, Yan; Luo, Yu; Pu, Kanyi
Advanced materials (Weinheim), 01/2021, Letnik: 33, Številka: 4Journal Article
Immunotherapy has offered new treatment options for cancer; however, the therapeutic benefits are often modest and desired to be improved. A semiconducting polymer nanoadjuvant (SPNIIR) with a photothermally triggered cargo release for second near‐infrared (NIR‐II) photothermal immunotherapy is reported here. SPNIIR consists of a semiconducting polymer nanoparticle core as an NIR‐II photothermal converter, which is doped with a toll‐like receptor (TLR) agonist as an immunotherapy adjuvant and coated with a thermally responsive lipid shell. Upon NIR‐II photoirradiation, SPNIIR effectively generates heat not only to ablate tumors and induce immunogenic cell death (ICD), but also to melt the lipid layers for on‐demand release of the TLR agonist. The combination of ICD and activation of TLR7/TLR8 enhances the maturation of dendritic cells, which amplifies anti‐tumor immune responses. Thus, a single treatment of SPNIIR‐mediated NIR‐II photothermal immunotherapy effectively inhibits growth of both primary and distant tumors and eliminates lung metastasis in a murine mouse model. This study thus provides a remote‐controlled smart delivery system to synergize photomedicine with immunotherapy for enhanced cancer treatment. A second near‐infrared (NIR‐II) photothermal semiconducting polymer nanoadjuvant is developed for enhanced cancer immunotherapy. Upon NIR‐II photoirradiation, the nanoadjuvant exerts photothermal effect to induce immunogenic cell death and on‐demand release of toll‐like receptor agonist, which enhances dendritic cell maturation. A synergistic action of photothermal immunotherapy thus occurs to inhibit the growth of primary and distant tumors and eliminate lung metastasis.
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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