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Harrison, Ewan M.; Paterson, Gavin K.; Holden, Matthew T.G.; Larsen, Jesper; Stegger, Marc; Larsen, Anders Rhod; Petersen, Andreas; Skov, Robert L.; Christensen, Judit Marta; Bak Zeuthen, Anne; Heltberg, Ole; Harris, Simon R.; Zadoks, Ruth N.; Parkhill, Julian; Peacock, Sharon J.; Holmes, Mark A.
EMBO molecular medicine, April 2013, Letnik: 5, Številka: 4Journal Article
Several methicillin‐resistant Staphylococcus aureus (MRSA) lineages that carry a novel mecA homologue (mecC) have recently been described in livestock and humans. In Denmark, two independent human cases of mecC‐MRSA infection have been linked to a livestock reservoir. We investigated the molecular epidemiology of the associated MRSA isolates using whole genome sequencing (WGS). Single nucleotide polymorphisms (SNP) were defined and compared to a reference genome to place the isolates into a phylogenetic context. Phylogenetic analysis revealed two distinct farm‐specific clusters comprising isolates from the human case and their own livestock, whereas human and animal isolates from the same farm only differed by a small number of SNPs, which supports the likelihood of zoonotic transmission. Further analyses identified a number of genes and mutations that may be associated with host interaction and virulence. This study demonstrates that mecC‐MRSA ST130 isolates are capable of transmission between animals and humans, and underscores the potential of WGS in epidemiological investigations and source tracking of bacterial infections. →See accompanying article http://dx.doi.org/10.1002/emmm.201302622 The promise of whole genome sequencing in epidemiological investigations and the source tracking of bacterial infections is exemplified here by the discovery of potential zoonotic transmission of methicillin‐resistant Staphylococcus aureus strains.
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