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Shaw, Tovah N; Houston, Stephanie A; Wemyss, Kelly; Bridgeman, Hayley M; Barbera, Thomas A; Zangerle-Murray, Tamsin; Strangward, Patrick; Ridley, Amanda J L; Wang, Ping; Tamoutounour, Samira; Allen, Judith E; Konkel, Joanne E; Grainger, John R
The Journal of experimental medicine, 06/2018, Letnik: 215, Številka: 6Journal Article
A defining feature of resident gut macrophages is their high replenishment rate from blood monocytes attributed to tonic commensal stimulation of this site. In contrast, almost all other tissues contain locally maintained macrophage populations, which coexist with monocyte-replenished cells at homeostasis. In this study, we identified three transcriptionally distinct mouse gut macrophage subsets that segregate based on expression of Tim-4 and CD4. Challenging current understanding, Tim-4 CD4 gut macrophages were found to be locally maintained, while Tim-4 CD4 macrophages had a slow turnover from blood monocytes; indeed, Tim-4 CD4 macrophages were the only subset with the high monocyte-replenishment rate currently attributed to gut macrophages. Moreover, all macrophage subpopulations required live microbiota to sustain their numbers, not only those derived from blood monocytes. These findings oppose the prevailing paradigm that all macrophages in the adult mouse gut rapidly turn over from monocytes in a microbiome-dependent manner; instead, these findings supplant it with a model of ontogenetic diversity where locally maintained subsets coexist with rapidly replaced monocyte-derived populations.
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in: SICRIS
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