E-viri
Recenzirano
Odprti dostop
-
Bazan-Socha, Stanislawa; Buregwa-Czuma, Sylwia; Jakiela, Bogdan; Zareba, Lech; Zawlik, Izabela; Myszka, Aleksander; Soja, Jerzy; Okon, Krzysztof; Zarychta, Jacek; Kozlik, Paweł; Dziedzina, Sylwia; Padjas, Agnieszka; Wojcik, Krzysztof; Kepski, Michal; Bazan, Jan G
International journal of molecular sciences, 01/2021, Letnik: 22, Številka: 3Journal Article
Airway remodeling in asthma is characterized by reticular basement membrane (RBM) thickening, likely related to epithelial structural and functional changes. Gene expression profiling of the airway epithelium might identify genes involved in bronchial structural alterations. We analyzed bronchial wall geometry (computed tomography (CT)), RBM thickness (histology), and the bronchial epithelium transcriptome profile (gene expression array) in moderate to severe persistent ( = 21) vs. no persistent ( = 19) airflow limitation asthmatics. RBM thickness was similar in the two studied subgroups. Among the genes associated with increased RBM thickness, the most essential were those engaged in cell activation, proliferation, and growth (e.g., , , , and ) and inhibiting apoptosis (e.g., higher mRNA expression of , , , and lower of , , ). Additionally, RBM thickness correlated with the expression of genes encoding extracellular matrix (ECM) components ( , ), involved in ECM remodeling ( ), neovascularization ( , ), nerve functioning ( , ), oxidative stress adaptation ( , ), epigenetic modifications ( , ), and the innate immune response ( , ). Cluster analysis revealed that genes linked with RBM thickness were also related to thicker bronchial walls in CT. Our study suggests that the pro-fibrotic profile in the airway epithelial cell transcriptome is associated with a thicker RBM, and thus, may contribute to asthma airway remodeling.
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.