In order to assess the effect of soil water deficit (SWD) during fruit development and ripening, on yield and quality of processing tomato under deficit irrigation in the Mediterranean climate, an open-field experiment was carried out in two sites differing from soil and climatic characteristics, in Sicily, South Italy. Six irrigation treatments were studied: no irrigation following plant establishment (NI); 100% (F = full) or 50% (D = deficit) ET c restoration with long-season irrigation (L) or short-season irrigation up to 1st fruit set (S); and long-season irrigation with 100% ET c restoration up to beginning of flowering, then 50% ET c restoration (LFD). The greatest effect of increasing SWD was the rise in fruit firmness, total solids and soluble solids (SS). A negative trend in response to increasing SWD was observed for fruit yield and size. Tough yield and SS were negatively correlated, the final SS yield under the LD regime was close to that of LF, and 47% water was saved. However, SS seems to be more environmental sensitive than SWD, since it varied more between sites than within site. The variations between sites in fruit quality response to deficit irrigation demonstrate that not only SWD but also soil and climatic characteristics influence the quality traits of the crop.