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Zarębska-Michaluk, Dorota; Jaroszewicz, Jerzy; Parfieniuk-Kowerda, Anna; Pawłowska, Małgorzata; Janczewska, Ewa; Berak, Hanna; Janocha-Litwin, Justyna; Klapaczyński, Jakub; Tomasiewicz, Krzysztof; Piekarska, Anna; Krygier, Rafał; Citko, Jolanta; Tronina, Olga; Dobrowolska, Krystyna; Flisiak, Robert
Journal of clinical medicine, 01/2022, Letnik: 11, Številka: 2Journal Article
The introduction of the direct-acting antivirals (DAA) has substantially improved the effectiveness of the therapy in patients with chronic hepatitis C. We aimed to compare the efficacy of pangenotypic and genotype-specific DAA in the cohort of genotype (GT) four patients with HCV monoinfection and HIV coinfection. A total of 662 GT4-infected patients treated in 2015-2020-of whom 168 (25.3%) were coinfected with HIV, selected from the retrospective EpiTer-2 database-were enrolled in the analysis. Among HIV-coinfected patients, 54% (90) were treated with genotype-specific regimens and 46% (78) with pangenotypic options, while among HCV-monoinfected patients, the rates were 72% and 28%, respectively. Significantly higher rate of males (67.9% vs. 57.7%, = 0.01), a lower rate of liver cirrhosis (10.2% vs. 18.1%, = 0.02), and higher of treatment-naïve patients (87.5% vs. 76.7%, = 0.003) were documented in the HIV coinfected population. The overall sustained virologic response after exclusion of non-virologic failures was achieved in 98% with no significant difference between HIV-positive and HIV-negative patients, 96.2% vs. 98.5%, respectively. While the genotype-specific regimens resulted in a similar cure rate regardless of the HIV status, the pangenotypic options were more efficacious in patients with HCV monoinfection (99.3% vs. 94.4%, = 0.05). Hereby, we demonstrated the high effectiveness and good safety profile of the DAA therapy in the population of HCV GT4 infected patients with HIV coinfection supporting the current recommendations to treat HCV/HIV coinfected patients with the same options as those with HCV monoinfection.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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