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Benzoquinoline Derivatives: An Attractive Approach to Newly Small Molecules with Anticancer ActivityOniciuc, Liliana; Amăriucăi-Mantu, Dorina; Diaconu, Dumitrela; Mangalagiu, Violeta; Danac, Ramona; Antoci, Vasilichia; Mangalagiu, Ionel I
International journal of molecular sciences, 2023-May-01, 2023-05-01, 20230501, Letnik: 24, Številka: 9Journal Article
This study presents the synthesis, structural characterization, and in vitro evaluation of anticancer activity of some newly benzo quinoline derivatives. The synthesis is facile and efficient, involving two steps: quaternization of nitrogen heterocycle followed by a 3+2 dipolar cycloaddition reaction. The synthesized compounds were characterized by FTIR, NMR, and X-ray diffraction on monocrystal in the case of compounds and . An in vitro single-dose anticancer assay of eighteen benzo quinoline compounds, quaternary salts, and cycloadducts, was performed. The results showed that the most active compounds were quaternary salts and with aromatic R substituents. Quaternary salt revealed non-selective activity against all types of cancer cells, while salt exhibited a highly selective activity against leukemia cells. Compound also presented remarkable cytotoxic efficiency against four distinct types of cancer cells-namely, non-small cell lung cancer HOP-92, melanoma LOX IMVI, melanoma SK-MEL-5, and breast cancer MDA-MB-468. Compound was selected for five-dose screening. The study also includes SAR correlations.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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