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Durduran, Turgut; Zhou, Chao; Buckley, Erin M; Kim, Meeri N; Yu, Guoqiang; Choe, Regine; Gaynor, J. William; Spray, Thomas L; Durning, Suzanne M; Mason, Stefanie E; Montenegro, Lisa M; Nicolson, Susan C; Zimmerman, Robert A; Putt, Mary E; Wang, Jiongjiong; Greenberg, Joel H; Detre, John A; Yodh, Arjun G; Licht, Daniel J
Journal of Biomedical Optics, 05/2010, Letnik: 15, Številka: 3Journal Article
We employ a hybrid diffuse correlation spectroscopy (DCS) and near-infrared spectroscopy (NIRS) monitor for neonates with congenital heart disease (n=33). The NIRS-DCS device measured changes during hypercapnia of oxyhemoglobin, deoxyhemoglobin, and total hemoglobin concentrations; cerebral blood flow (rCBF ); and oxygen metabolism (rCMRO ). Concurrent measurements with arterial spin-labeled magnetic resonance imaging (rCBF , n=12) cross-validate rCBF against rCBF , showing good agreement (R=0.7, p=0.01). The study demonstrates use of NIRS-DCS on a critically ill neonatal population, and the results indicate that the optical technology is a promising clinical method for monitoring this population.
