E-viri
PDF
Recenzirano
Odprti dostop
-
Strebel, Klaus; Luban, Jeremy; Jeang, Kuan-Teh
BMC medicine, 09/2009, Letnik: 7, Številka: 1Journal Article
Recent findings have highlighted roles played by innate cellular factors in restricting intracellular viral replication. In this review, we discuss in brief the activities of apolipoprotein B mRNA-editing enzyme 3G (APOBEC3G), bone marrow stromal cell antigen 2 (BST-2), cyclophilin A, tripartite motif protein 5 alpha (Trim5alpha), and cellular microRNAs as examples of host restriction factors that target HIV-1. We point to countermeasures encoded by HIV-1 for moderating the potency of these cellular restriction functions.
