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Cherednichenko, A. G.; Dymova, M. A.; Solodilova, O. A.; Petrenko, T. I.; Prozorov, A. I.; Filipenko, M. L.
Bulletin of experimental biology and medicine, 03/2016, Letnik: 160, Številka: 5Journal Article
Genotyping and analysis the drug resistance of 59 isolates of M. tuberculosis obtained from patients living in Altai Territory were performed using a BACTEC MGIT 960 fluorometric system by means of VNTR typing (variable number tandem repeat), PCR-RFLP analysis, and sequence analysis. The occurrence frequency was highest for isolates of the Beijing family ( n =30, 50.8%). Analysis of mutation spectrum in the rpoB gene associated with rifampicin resistance revealed the major mutation (codon 531 of the rpoB gene) in 93% samples, which allows us to use rapid test systems.
