OBJECTIVE:Evaluation of the effectiveness of a workplace health promotion program on employees’ vitality, health, and work-related outcomes, and exploring the influence of organizational support and the supervisors’ role on these outcomes. METHODS:The 5-month intervention included activities at management, team, and individual level targeting self-management to perform healthy behaviorsa kick-off session, vitality training sessions, workshops, individual coaching, and intervision. Outcome measures were collected using questionnaires, health checks, and sickness absence data at baseline, after the intervention and at 10 months follow-up. For analysis linear and generalized mixed models were used. RESULTS:Vitality, work performance, sickness absence, and self-management significantly improved. Good organizational support and involved supervisors were significantly associated with lower sickness absence. CONCLUSIONS:Including all organizational levels and focusing on increasing self-management provided promising results for improving vitality, health, and work-related outcomes.