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Sawano, Shoko; Fukushima, Misaki; Akasaka, Taiki; Nakamura, Mako; Tatsumi, Ryuichi; Ikeuchi, Yoshihide; Mizunoya, Wataru
Life, 04/2023, Letnik: 13, Številka: 5Journal Article
Skeletal muscle atrophy occurs rapidly as a result of inactivity. Although there are many reports on changes in gene expression during the early phase of muscle atrophy, the patterns of up-and downregulated gene expression after long-term and equilibrated muscle atrophy are poorly understood. In this study, we comprehensively examined the changes in gene expression in long-term denervated mouse muscles using RNA-Seq. The murine right sciatic nerve was denervated, and the mice were housed for five weeks. The cross-sectional areas of the hind limb muscles were measured using an X-ray CT system 35 days after denervation. After 28 d of denervation, the cross-sectional area of the muscle decreased to approximately 65% of that of the intact left muscle and reached a plateau. Gene expression in the soleus and extensor digitorum longus (EDL) muscles on the 36th day was analyzed using RNA-Seq and validated using RT-qPCR. RNA-Seq analysis revealed that three genes- , and -were upregulated and one gene- -was downregulated in the soleus muscle; additionally, four genes- , , , and -were upregulated and one gene- -was downregulated in the EDL muscle (FDR < 0.05). Among these genes, , one of the long non-coding RNAs, was significantly upregulated in both the muscles. These findings indicate that could be a candidate gene for the maintenance of atrophied skeletal muscle size and an atrophic state.
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