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Piccinin, Elena; Arconzo, Maria; Graziano, Giusi; Vacca, Michele; Peres, Claudia; Bellafante, Elena; Villani, Gaetano; Moschetta, Antonio
International journal of molecular sciences, 11/2019, Letnik: 20, Številka: 22Journal Article
The fine-tuning of liver metabolism is essential to maintain the whole-body homeostasis and to prevent the onset of diseases. The peroxisome proliferator-activated receptor-γ coactivators (PGC-1s) are transcriptional key players of liver metabolism, able to regulate mitochondrial function, gluconeogenesis and lipid metabolism. Their activity is accurately modulated by post-translational modifications. Here, we showed that specific PGC-1s expression can lead to the upregulation of different microRNAs widely implicated in liver physiology and diseases development and progression, thus offering a new layer of complexity in the control of hepatic metabolism.
