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Li, Sheng; Han, Ling-Ling; Huang, Ke-Pu; Ma, Ye-Han; Guo, Ling-Li; Guo, Yarong; Ran, Xiaoqian; Yao, Yong-Gang; Hao, Xiao-Jiang; Luo, Rongcan; Zhang, Yu
International journal of molecular sciences, 01/2023, Letnik: 24, Številka: 2Journal Article
Eleven monoterpenoid indole alkaloids, including three new ones, tabercrassines A-C ( - ), were isolated from the seeds of . Tabercrassine A ( ) is an ibogan-ibogan-type bisindole alkaloid which is formed by the polymerization of two classic ibogan-type monomers through a C3 unit aliphatic chain. Their structures were established by extensive analysis of HRESIMS, NMR, and ECD spectra. Cellular assays showed that alkaloids - all reduce A 42 production and inhibit phospho-tau (Thr217), a new biomarker of Alzheimer's disease AD associated with BACE1-, NCSTN-, GSK3β-, and CDK5-mediated pathways, suggesting these alkaloids' potential against AD.
