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Aragão, Luiz Guilherme H S; Oliveira, Júlia T; Temerozo, Jairo R; Mendes, Mayara A; Salerno, José Alexandre; Pedrosa, Carolina S G; Puig-Pijuan, Teresa; Veríssimo, Carla P; Ornelas, Isis M; Torquato, Thayana; Vitória, Gabriela; Sacramento, Carolina Q; Fintelman-Rodrigues, Natalia; da Silva Gomes Dias, Suelen; Cardoso Soares, Vinicius; Souza, Letícia R Q; Karmirian, Karina; Goto-Silva, Livia; Biagi, Diogo; Cruvinel, Estela M; Dariolli, Rafael; Furtado, Daniel R; Bozza, Patrícia T; Borges, Helena L; Souza, Thiago M L; Guimarães, Marília Zaluar P; Rehen, Stevens K
PeerJ (San Francisco, CA), 10/2021, Letnik: 9Journal Article
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which can infect several organs, especially impacting respiratory capacity. Among the extrapulmonary manifestations of COVID-19 is myocardial injury, which is associated with a high risk of mortality. Myocardial injury, caused directly or indirectly by SARS-CoV-2 infection, can be triggered by inflammatory processes that lead to damage to the heart tissue. Since one of the hallmarks of severe COVID-19 is the "cytokine storm", strategies to control inflammation caused by SARS-CoV-2 infection have been considered. Cannabinoids are known to have anti-inflammatory properties by negatively modulating the release of pro-inflammatory cytokines. Herein, we investigated the effects of the cannabinoid agonist WIN 55,212-2 (WIN) in human iPSC-derived cardiomyocytes (hiPSC-CMs) infected with SARS-CoV-2. WIN did not modify angiotensin-converting enzyme II protein levels, nor reduced viral infection and replication in hiPSC-CMs. On the other hand, WIN reduced the levels of interleukins six, eight, 18 and tumor necrosis factor-alpha (TNF-α) released by infected cells, and attenuated cytotoxic damage measured by the release of lactate dehydrogenase (LDH). Our findings suggest that cannabinoids should be further explored as a complementary therapeutic tool for reducing inflammation in COVID-19 patients.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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