E-viri
Recenzirano
Odprti dostop
-
Eckert, Alexander J.; Zimny, Stefan; Altmeier, Marcus; Dugic, Ana; Gillessen, Anton; Bozkurt, Latife; Götz, Gabriele; Karges, Wolfram; Wosch, Frank J.; Kress, Stephan; Holl, Reinhard W.
Journal of diabetes, February 2024, Letnik: 16, Številka: 2Journal Article
Aims Diabetic foot ulcer (DFU) is a leading cause of lower limb amputations in people with diabetes. This study was aimed to retrospectively analyze factors affecting DFU using real‐world data from a large, prospective central‐European diabetes registry (DPV Diabetes‐Patienten‐Verlaufsdokumentation). Materials and Methods We matched adults with type 1 (T1D) or type 2 diabetes (T2D) and DFU to controls without DFU by diabetes type, age, sex, diabetes duration, and treatment year to compare possible risk factors. Cox regression was used to calculate hazard ratios for amputation among those with DFU. Results In our cohort (N = 63 464), male sex, taller height, and diabetes complications such as neuropathy, peripheral artery disease, nephropathy, and retinopathy were associated with DFU (all p < .001). Glycated hemoglobin (HbA1c) was related to DFU only in T1D (mean with 95% confidence interval CI: 7.8 6.9–9.0 % vs 7.5 6.8–8.5 %, p < .001). High triglycerides and worse low‐density lipoprotein/high‐density lipoprotein ratio were also associated with DFU in T1D, whereas smoking (14.7% vs 13.1%) and alcohol abuse (6.4% vs 3.8%, both p < .001) were associated with DFU in T2D. Male sex, higher Wagner grades, and high HbA1c in both diabetes types and insulin use in T2D were associated with increased hazard ratios for amputations. Conclusions Sex, body height, and diabetes complications were associated DFU risk in adults with T1D and T2D. Improvement in glycemic control and lipid levels in T1D and reduction of smoking and drinking in T2D may be appropriate interventions to reduce the risk for DFU or amputations. Highlights Poor glycemic control and high lipid levels were associated more closely with diabetic foot ulcers in type 1 compared to type 2 diabetes. Gender differences regarding the association of diabetic foot ulcers with metabolic outcomes were more pronounced in type 1 diabetes. Smoking and alcohol consumption might be important in developing foot ulcers but play a minor role in prevention of amputations. The role of oral hypoglycemic medication in development of diabetic foot ulcers should be further analyzed in type 2 diabetes.
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.