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Jiang, Xiangyi; Yu, Ji; Zhou, Zhongxia; Kongsted, Jacob; Song, Yuning; Pannecouque, Christophe; De Clercq, Erik; Kang, Dongwei; Poongavanam, Vasanthanathan; Liu, Xinyong; Zhan, Peng
Medicinal research reviews, November 2019, Letnik: 39, Številka: 6Journal Article
Solvent‐exposed regions, or solvent‐filled pockets, within or adjacent to the ligand‐binding sites of drug‐target proteins provide opportunities for substantial modifications of existing small‐molecular drug molecules without serious loss of activity. In this review, we present recent selected examples of exploitation of solvent‐exposed regions of proteins in drug design and development from the recent medicinal‐chemistry literature. The solvent‐exposed regions of target proteins provided great opportunities to molecular design.
