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Yeh, Wen-Chen; de la Pompa, José Luis; McCurrach, Mila E.; Shu, Hong-Bing; Elia, Andrew J.; Shahinian, Arda; Ng, Michelle; Wakeham, Andrew; Khoo, Wilson; Mitchell, Kyran; El-Deiry, Wafik S.; Lowe, Scott W.; Goeddel, David V.
Science (American Association for the Advancement of Science), 03/1998, Letnik: 279, Številka: 5358Journal Article
FADD (also known as Mort-1) is a signal transducer downstream of cell death receptor CD95 (also called Fas). CD95, tumor necrosis factor receptor type 1 (TNFR-1), and death receptor 3 (DR3) did not induce apoptosis in FADD-deficient embryonic fibroblasts, whereas DR4, oncogenes E1A and c-myc, and chemotherapeutic agent adriamycin did. Mice with a deletion in the FADD gene did not survive beyond day 11.5 of embryogenesis; these mice showed signs of cardiac failure and abdominal hemorrhage. Chimeric embryos showing a high contribution of FADD null mutant cells to the heart reproduce the phenotype of FADD-deficient mutants. Thus, not only death receptors, but also receptors that couple to developmental programs, may use FADD for signaling.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Vir: Osebne bibliografije
in: SICRIS
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