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Winckler, Wendy; Myers, Simon R.; Richter, Daniel J.; Onofrio, Robert C.; McDonald, Gavin J.; Bontrop, Ronald E.; Gilean A. T. Mc Vean; Gabriel, Stacey B.; Reich, David; Donnelly, Peter; Altshuler, David
Science, 04/2005, Letnik: 308, Številka: 5718Journal Article
We compared fine-scale recombination rates at orthologous loci in humans and chimpanzees by analyzing polymorphism data in both species. Strong statistical evidence for hotspots of recombination was obtained in both species. Despite ~99% identity at the level of DNA sequence, however, recombination hotspots were found rarely (if at all) at the same positions in the two species, and no correlation was observed in estimates of fine-scale recombination rates. Thus, local patterns of recombination rate have evolved rapidly, in a manner disproportionate to the change in DNA sequence.
