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Horikoshi, Momoko; Mook-Kanamori, Dennis O; Hennig, Branwen J; Bradfield, Jonathan P; St Pourcain, Beate; Charoen, Pimphen; Kaakinen, Marika; Lehtimäki, Terho; Kreiner-Møller, Eskil; Warrington, Nicole M; Bustamante, Mariona; Feenstra, Bjarke; Berry, Diane J; Shields, Beverley M; Kerkhof, Marjan; van Leeuwen, Elisabeth M; Zhao, Jing Hua; den Hoed, Marcel; Mahajan, Anubha; Lindi, Virpi; Goh, Liang-Kee; Raitakari, Olli T; Harder, Marie N; Meirhaeghe, Aline; Ntalla, Ioanna; Salem, Rany M; Jameson, Karen A; Zhou, Kaixin; Monies, Dorota M; Lagou, Vasiliki; Heikkinen, Jani; Al-Odaib, Ali; Amouyel, Philippe; Bennett, Amanda J; Blakemore, Alexandra I F; Buxton, Jessica L; Das, Shikta; de Geus, Eco J C; Flexeder, Claudia; Froguel, Philippe; Geller, Frank; Gottrand, Frédéric; Groves, Christopher J; Hansen, Torben; Hofman, Albert; Hollegaard, Mads V; Hyppönen, Elina; Inskip, Hazel M; Isaacs, Aaron; Jørgensen, Torben; Kanaka-Gantenbein, Christina; Kemp, John P; Kilpeläinen, Tuomas O; Klopp, Norman; Kuzawa, Christopher W; McMahon, George; Newnham, John P; Rivadeneira, Fernando; Simell, Olli; Slowinski, Torsten; Tiesler, Carla M T; Tönjes, Anke; Vaag, Allan; Vissing, Nadja Hawwa; Willemsen, Gonneke; Witte, Daniel R; Zhang, Haitao; Zhao, Jianhua; Wilson, James F; Stumvoll, Michael; Prentice, Andrew M; Meyer, Brian F; Pearson, Ewan R; Boreham, Colin A G; Cooper, Cyrus; Gillman, Matthew W; Moreno, Luis A; Pedersen, Oluf; Saarinen, Maiju; Mohlke, Karen L; Saw, Seang-Mei; Loos, Ruth J F; Ong, Ken K; Vollenweider, Peter; Hattersley, Andrew T; Holloway, John W; Hocher, Berthold; Guxens, Mònica; Bisgaard, Hans; Eriksson, Johan G; Widén, Elisabeth; Hakonarson, Hakon; Uitterlinden, André G; Pouta, Anneli; Smith, George Davey; Frayling, Timothy M; Grant, Struan F A; Jaddoe, Vincent W V; Prokopenko, Inga; Freathy, Rachel M
Nature genetics, 01/2013, Letnik: 45, Številka: 1Journal Article
Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood. Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits. In an expanded genome-wide association meta-analysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism.
