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O'Dushlaine, Colm; Chambert, Kimberly; Akterin, Susanne; Collins, Ann L; Crowley, James J; Fromer, Menachem; Magnusson, Patrik K E; Sanchez, Nick; Stahl, Eli A; Williams, Stephanie; Xia, Kai; Bettella, Francesco; Cormican, Paul; Craddock, Nick; Golimbet, Vera; Hamshere, Marian L; Hougaard, David M; Morris, Derek W; Neale, Benjamin M; O'Neill, Francis A; Owen, Michael J; Milovancevic, Milica Pejovic; Powell, John; Rujescu, Dan; Sigurdsson, Engilbert; Silagadze, Teimuraz; Smit, August B; Stefansson, Hreinn; Suvisaari, Jaana; Tosato, Sarah; Verhage, Matthijs; Walters, James T; Mowry, Bryan J; O'Donovan, Michael C; Wildenauer, Dieter B; Shi, Jianxin; Albus, Margot; Alexander, Madeline; Dikeos, Dimitris; Duan, Jubao; Eichhammer, Peter; Hansen, Mark; Lerer, F Bernard; Mallet, Jacques; Nertney, Deborah A; Nestadt, Gerald; Papadimitriou, George N; Silverman, Jeremy M; Arranz, Maria J; Bakker, Steven; Bramon, Elvira; Collier, David; Crespo-Facorro, Benedicto; Jablensky, Assen; Kalaydjieva, Luba; Lawrie, Stephen; Lewis, Cathryn M; Linszen, Don H; Mata, Ignacio; Ophoff, Roel A; Weisbrod, Matthias; Wiersma, Durk; Barroso, Ines; Blackwell, Jenefer M; Brown, Matthew A; Casas, Juan P; Jankowski, Janusz; Markus, Hugh S; Mathew, Christopher G; Palmer, Colin N A; Plomin, Robert; Sawcer, Stephen J; Viswanathan, Ananth C; Spencer, Chris C A; Band, Gavin; Bellenguez, Céline; Freeman, Colin; Hellenthal, Garrett; Pearson, Richard D; Su, Zhan; Langford, Cordelia; Bumpstead, Suzannah J; Dronov, Serge; Gillman, Matthew; Gray, Emma; Jayakumar, Alagurevathi; McCann, Owen T; Potter, Simon C; Ricketts, Michelle; Tashakkori-Ghanbaria, Avazeh; Waller, Matthew J; Weston, Paul; Whittaker, Pamela; McCarthy, Mark I; Stefansson, Kari; Scolnick, Edward; Purcell, Shaun; McCarroll, Steven A; Sklar, Pamela; Sullivan, Patrick F
Nature genetics, 10/2013, Letnik: 45, Številka: 10Journal Article
Schizophrenia is an idiopathic mental disorder with a heritable component and a substantial public health impact. We conducted a multi-stage genome-wide association study (GWAS) for schizophrenia beginning with a Swedish national sample (5,001 cases and 6,243 controls) followed by meta-analysis with previous schizophrenia GWAS (8,832 cases and 12,067 controls) and finally by replication of SNPs in 168 genomic regions in independent samples (7,413 cases, 19,762 controls and 581 parent-offspring trios). We identified 22 loci associated at genome-wide significance; 13 of these are new, and 1 was previously implicated in bipolar disorder. Examination of candidate genes at these loci suggests the involvement of neuronal calcium signaling. We estimate that 8,300 independent, mostly common SNPs (95% credible interval of 6,300-10,200 SNPs) contribute to risk for schizophrenia and that these collectively account for at least 32% of the variance in liability. Common genetic variation has an important role in the etiology of schizophrenia, and larger studies will allow more detailed understanding of this disorder.
